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J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Sep 1;841(1-2):52-64. Epub 2006 May 2.

Less common applications of monoliths: preconcentration and solid-phase extraction.

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  • The Molecular Foundry, E.O. Lawrence Berkeley National Laboratory, Berkeley, CA 94720-8139, USA. svec@berkeley.edu


Monolithic materials are finding their place in a variety of fields. While liquid chromatography is the most emphasized use of this new category of porous media, some other just as important applications are eclipsed by the success of monolithic columns. This review article describes all current facets of use of monoliths in preconcentration and solid-phase extraction. In addition to the typical off line use that does not seem to be the main stream application for the monolithic materials, in-line connection of the preconcentration with HPLC, electrochromatography, electrophoresis, enzymatic digestion, as well as its applications in microfluidics are presented.

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