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Gastrointest Endosc. 2006 May;63(6):776-82.

Clinical outcomes of EMR for gastric tumors: historical pilot evaluation between endoscopic submucosal dissection and conventional mucosal resection.

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  • 1Department of Internal Medicine, Radiology, Pathology, Saga Prefectural Hospital Koseikan, Saga Japan.

Abstract

BACKGROUND:

EMR is currently a standard treatment for mucosal gastric tumors. Endoscopic submucosal dissection (ESD) has been developed for en bloc resection.

OBJECTIVE:

We evaluated the clinical outcomes of ESD compared with conventional EMR.

DESIGN:

Not applicable.

SETTING:

A historical control study was performed between EMR and ESD.

PATIENTS:

EMR of 245 gastric tumors was performed in 229 patients. Lesions were divided into two groups. Conventional EMR was performed in group A from February 1999 to June 2001, and ESD was performed in group B from July 2001 to March 2004. Group B was divided into subgroups: subgroup B-1 underwent ESD from July 2001 to March 2003 and subgroup B-2 from April 2003 to March 2004.

INTERVENTIONS:

All lesions were resected with conventional EMR or with ESD.

MAIN OUTCOME MEASUREMENTS:

En bloc resection rate, rate in completeness of resection, required time, remnant ratio, and complications were evaluated.

RESULTS:

With regard to lesions >10 mm in size, the en bloc resection rate and the rate in completeness of resection of group B was significantly higher than that of group A (p < 0.01). Although the required time was longer in group B than A (p < 0.01), it was shorter in subgroup B-2 compared with B-1 (p < 0.05) with lesions < or =10 mm in size. The remnant ratio and perforation rate were not different between groups.

LIMITATIONS:

Not applicable.

CONCLUSIONS:

The en bloc resection rate was better with ESD than with conventional EMR. The required time was longer in ESD, but this disadvantage might be improved with experience.

PMID:
16650537
[PubMed - indexed for MEDLINE]
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