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1: Pediatr Dermatol. 2006 Mar-Apr;23(2):179-82.Click here to read Links

Albendazole: single or combination therapy with permethrin against pediculosis capitis.

Akisu C, Delibas SB, Aksoy U.

Dokuz Eylul University, Medical Faculty, Department of Parasitology, Izmir, Turkey. ciler.akisu@deu.edu.tr

Pediculosis capitis is a worldwide problem and a growing concern because of resistance to pediculicides. In the present study, we investigated whether albendazole could be used in the treatment of pediculosis capitis in combination with 1% permethrin or alone. A total of 150 children were randomly divided to five groups of 30 each. Group 1 got albendazole in a single dose (400 mg), group 2 got albendazole at 400 mg for 3 days, group 3 was given 1% permethrin, group 4 took 1% permethrin and albendazole in a single dose (400 mg), and group 5 got 1% permethrin and albendazole in a dose of 400 mg for 3 days. Groups given albendazole were also given another 400 mg dose of albendazole after 1 week. The success rate of treatment at the 2-week follow-up for all groups was 61.5%, 66.6%, 80.0%, 84.6%, and 82.1%, respectively. No statistically significant difference was found between the groups. The results of this study suggest that albendazole is effective against pediculosis capitis and there is no synergistic effect between albendazole and 1% permethrin.

PMID: 16650232 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Permethrin (Elimite® , Nix® Creme Rinse)

    Permethrin kills parasites and their eggs. It is used to treat scabies (a skin infestation) and lice infestations of the head, body, and pubic area ('crabs'). Permethrin does not prevent these infestations.

  • Source: AHFS Consumer Medication Information