Eur J Pediatr. 2006 Sep;165(9):590-3. Epub 2006 Apr 29.

Idiopathic infantile arterial calcification: clinical presentation, therapy and long-term follow-up.

van der Sluis IM, Boot AM, Vernooij M, Meradji M, Kroon AA.

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Department of Paediatrics, Erasmus Medical Centre, Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands. i.vandersluis@erasmusmc.nl

Abstract

Idiopathic infantile arterial calcification (IIAC) is a rare disease characterised by extensive depositions of hydroxyapatite in the internal elastic lamina of medium-sized and large arteries, frequently accompanied by periarticular calcifications. We report on three patients with various presenting signs and symptoms. Diagnostic imaging techniques and therapy with bisphosphonates will be discussed. For the first time long-term follow-up of up to 25 years will be reported.

PMID:: 16649023; [PubMed - indexed for MEDLINE]

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