Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Stat Appl Genet Mol Biol. 2004;3:Article29. Epub 2004 Oct 31.

MergeMaid: R tools for merging and cross-study validation of gene expression data.

Author information

  • 1The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, USA. cope@jhu.edu

Abstract

Cross-study validation of gene expression investigations is critical in genomic analysis. We developed an R package and associated object definitions to merge and visualize multiple gene expression datasets. Our merging functions use arbitrary character IDs and generate objects that can efficiently support a variety of joint analyses. Visualization tools support exploration and cross-study validation of the data, without requiring normalization across platforms. Tools include "integrative correlation'' plots that is, scatterplots of all pairwise correlations in one study against the corresponding pairwise correlations of another, both for individual genes and all genes combined. Gene-specific plots can be used to identify genes whose changes are reliably measured across studies. Visualizations also include scatterplots of gene-specific statistics quantifying relationships between expression and phenotypes of interest, using linear, logistic and Cox regression.

PMID:
16646808
[PubMed]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for iFactory
    Loading ...
    Write to the Help Desk