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J Bone Joint Surg Br. 2006 May;88(5):634-6.

Familial chordoma. A report of two cases.

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  • 1National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK.


We have treated 175 patients with a chordoma over a ten-year period. Only two had a family history of the condition and we describe these in this paper. In one patient the tumour was at the craniocervical junction and in the other the lesion affected the sacrum. We have undertaken a literature review of familial chordoma and have identified chromosomal abnormalities associated with the condition.

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