Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity

Revecca Theodori; Anastasia Karioti; Ana Rancić; Helen Skaltsa

doi:10.1021/np058084i

Linear sesquiterpene lactones from Anthemis auriculata and their antibacterial activity

J Nat Prod. 2006 Apr;69(4):662-4. doi: 10.1021/np058084i.

Authors

Revecca Theodori¹, Anastasia Karioti, Ana Rancić, Helen Skaltsa

Affiliation

¹ Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, GR-157 71 Athens, Greece.

PMID: 16643047
DOI: 10.1021/np058084i

Abstract

Three linear sesquiterpene lactones, anthecotulide (1), hydroxyanthecotulide (2), and acetoxyanthecotulide (3), were isolated from the aerial parts of Anthemis auriculata. Five known flavonoids, taraxa-20(30)en-3beta-ol (4), and methyl vanillate (5) were also isolated. The structures and the relative configuration of the new compounds 2 and 3 were deduced by spectroscopic methods. The in vitro activity of compounds 1-5 against 10 bacterial species and one fungus was tested using the microdilution method.

MeSH terms

Anthemis / chemistry*
Anti-Infective Agents* / chemistry
Anti-Infective Agents* / isolation & purification
Anti-Infective Agents* / pharmacology
Candida albicans / drug effects
Flavonoids / chemistry
Flavonoids / isolation & purification
Flavonoids / pharmacology
Gram-Positive Bacteria / drug effects
Lactones* / chemistry
Lactones* / isolation & purification
Lactones* / pharmacology
Microbial Sensitivity Tests
Molecular Structure
Plants, Medicinal / chemistry*
Sesquiterpenes* / chemistry
Sesquiterpenes* / isolation & purification
Sesquiterpenes* / pharmacology

Substances

4-O-acetoxyanthecotulide
4-hydroxyanthecotulide
Anti-Infective Agents
Flavonoids
Lactones
Sesquiterpenes
anthecotulide