OBJECTIVE: To compare clinical therapeutic effects of acupoint catgut embedding therapy and medicine on premenstrual syndrome, so as to search for the best method for this disease. METHODS: Eighty-eight cases were randomly divided into a catgut embedding group and a medication group. The catgut embedding group were treated with main points, Neiguan (PC 6), Sanyinjiso (SP 6), Danzhong (CV 17), Guanyuan (CV 4), Taichong (LR 3), and aduvant points, Back-shu, and the medicine group with oral administration of fluoxetine. After treatment of 3 months, their therapeutic effects were compared. RESULTS: The therapeutic effect of the catgut embedding group was better than that of the medication group with a very statistically significant difference (P < 0.005). CONCLUSION: Acupoint catgut embedding is a better therapy for premenstrual syndrome.