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Trends Biochem Sci. 1991 Dec;16(12):478-81.

Nuclear targeting sequences--a consensus?

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  • 1Wellcome Trust/Cancer Research Campaign Institute of Cancer and Development Biology, Cambridge.

Abstract

Nuclear targeting sequences are essential for the transport of proteins into the nucleus. The seven-amino-acid nuclear targeting sequence of the SV40 large T antigen has been regarded as the model; however, many nuclear targeting sequences appear to be more complex. We suggest in this review that, despite this diversity, a consensus bipartite motif can be identified.

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PMID:
1664152
[PubMed - indexed for MEDLINE]
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