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    Antimicrob Agents Chemother. 2006 May;50(5):1865-8.

    Comparative in vitro efficacies of various catheter lock solutions.

    Sherertz RJ, Boger MS, Collins CA, Mason L, Raad II.

    Section on Infectious Diseases, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27517, USA. sherertz@wfubmc.edu

    MEDTA (minocycline-edetate calcium disodium), taurolidine (2%)-polyvinylpyrolidine (5%) (T/PVP), and ethanol as potential catheter lock solutions have a unique mechanism of action, broad-spectrum activity, and anticoagulant properties. Traditional lock solutions minocycline (M), rifampin (R), ciprofloxacin (C), and vancomycin, except pharmacologic concentrations of C and R and of M and R, were less effective than MEDTA and T/PVP.

    PMID: 16641463 [PubMed - indexed for MEDLINE]

    PMCID: 1472229

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