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Prostate. 2006 Jul 1;66(10):1082-5.

Germline ATBF1 mutations and prostate cancer risk.

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  • 1Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Abstract

BACKGROUND:

ATBF1 has been recently identified as a candidate prostate tumor suppressor gene. In addition to more unique mutations, two somatic mutations (shortening of a polypyrimidine tract [Poly(T)n] and a deletion beginning at codon 3381 (3381del)) were each observed in multiple prostate cancer samples and both appear to have an impact on ATBF1 gene function and expression.

METHODS:

We assayed two recurrent sequence variants in germline DNA from prostate cancer cases and controls, and examined whether carriers of these variants are at increased risk for prostate cancer.

RESULTS:

We found Poly(T)n variants in both normal and matched tumor DNA samples from multiple patients, indicating a germline origin in each case. Genotyping germline DNA samples indicated that 3381del was significantly associated with prostate cancer risk among sporadic cases (P = 0.03), but not among men with hereditary disease.

CONCLUSIONS:

Our study indicates that the germline 3381del allele may influence prostate cancer susceptibility.

Copyright 2005 Wiley-Liss, Inc.

PMID:
16637072
[PubMed - indexed for MEDLINE]
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