Pharmacol Ther. 1991;51(1):13-33.

Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function.

Source

Department of Pharmacology, University of South Alabama College of Medicine, Mobile.

Abstract

This article is a review of cyclic nucleotide phosphodiesterase(s) (CN PDE) from the point of view of the relationships between the newer aspects of the complex enzymology of CN PDE and recent major advances in CN PDE pharmacology. A consolidation of isozyme nomenclature to the proposed family designations is recommended. Emphasis is placed on the importance of defining the subcellular localization of isozymes expressed in a given tissue and cyclic GMP substrate and regulatory roles in CN PDE isozyme functions. CN PDE inhibitors that may be useful for experimental and clinical purposes are discussed. Examples of these inhibitors include CGS 9343B, TCV-3B, KW-6, MIMAX, Dihydroisoquinolines, Trequinsin, bipyridine and dihydropyridazinone cardiotonics, Rolipram, SQ 65442, Zaprinast and Dipyridamole.

PMID:: 1663250; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Elsevier Science

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Supplemental Content

Save items

Related citations in PubMed

Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle. [J Pharmacol Exp Ther. 1993]
Initial biochemical and functional characterization of cyclic nucleotide phosphodiesterase isozymes in canine colonic smooth muscle.
Barnette MS, Manning CD, Price WJ, Barone FC. J Pharmacol Exp Ther. 1993 Feb; 264(2):801-12.
Review Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma. [Prog Drug Res. 1993]
Review Isozyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma.
Raeburn D, Souness JE, Tomkinson A, Karlsson JA. Prog Drug Res. 1993; 40:9-32.
Review Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. [Trends Pharmacol Sci. 1991]
Review Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes.
Nicholson CD, Challiss RA, Shahid M. Trends Pharmacol Sci. 1991 Jan; 12(1):19-27.
Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources. [Naunyn Schmiedebergs Arch Phar...]
Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources.
Noguera MA, Ivorra MD, Lugnier C, D'Ocon P. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jun; 363(6):612-9.
Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. [Naunyn Schmiedebergs Arch Phar...]
Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes.
Sugioka M, Ito M, Masuoka H, Ichikawa K, Konishi T, Tanaka T, Nakano T. Naunyn Schmiedebergs Arch Pharmacol. 1994 Sep; 350(3):284-93.

See reviews... See all...

Cited by 26 PubMed Central articles

Review Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies. [Br J Pharmacol. 2010]
Review Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies.
Hill SJ, Williams C, May LT. Br J Pharmacol. 2010 Nov; 161(6):1266-75.
Review cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. [Pharmacol Rev. 2010]
Review cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
Francis SH, Busch JL, Corbin JD, Sibley D. Pharmacol Rev. 2010 Sep; 62(3):525-63.
Review ABCD of the phosphodiesterase family: interaction and differential activity in COPD. [Int J Chron Obstruct Pulmon Di...]
Review ABCD of the phosphodiesterase family: interaction and differential activity in COPD.
Halpin DM. Int J Chron Obstruct Pulmon Dis. 2008; 3(4):543-61.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function.
Cyclic nucleotide phosphodiesterases: pharmacology, biochemistry and function.
Pharmacol Ther. 1991 ;51(1):13-33.

PubMed
Exploiting indirect neighbours and topological weight to predict protein functio...
Exploiting indirect neighbours and topological weight to predict protein function from protein-protein interactions.
Bioinformatics. 2006 Jul 1 ;22(13):1623-30. Epub 2006 Apr 21 .

PubMed
Prostate cancer stem cells.
Prostate cancer stem cells.
Eur J Cancer. 2006 Jun ;42(9):1213-8. Epub 2006 May 2 .

PubMed
Pathologic reporting and special diagnostic techniques for melanoma.
Pathologic reporting and special diagnostic techniques for melanoma.
Surg Oncol Clin N Am. 2006 Apr ;15(2):231-51.

PubMed
Cognitive impairment in patients with chronic hepatitis treated with interferon ...
Cognitive impairment in patients with chronic hepatitis treated with interferon alpha (IFNalpha): results from a prospective study.
Eur Psychiatry. 2006 Apr ;21(3):204-10.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: