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Curr Biol. 2006 Apr 18;16(8):R296-9.

DNA repair: DNA polymerase zeta and Rev1 break in.

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  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.


DNA polymerase zeta and Rev1 play key roles in replication past DNA lesions. New work shows that the yeast checkpoint kinase Mec1 recruits a complex consisting of polymerase zeta and Rev1 to DNA double-strand breaks. This study highlights the role of polymerases that mediate translesion synthesis in the response to DNA double-strand breaks.

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