Pten, tumorigenesis, and stem cell self-renewal

Cell. 2006 Apr 21;125(2):229-31. doi: 10.1016/j.cell.2006.04.006.

Abstract

Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As Yilmaz et al. (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle / physiology*
  • Hematopoietic Stem Cells / physiology*
  • Homeostasis
  • Humans
  • Leukemia, Myeloid, Acute / metabolism*
  • Leukemia, Myeloid, Acute / physiopathology
  • PTEN Phosphohydrolase / genetics
  • PTEN Phosphohydrolase / metabolism*
  • Signal Transduction / physiology

Substances

  • PTEN Phosphohydrolase