Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor

F Libert; E Passage; M Parmentier; M J Simons; G Vassart; M G Mattei

doi:10.1016/0888-7543(91)90125-x

Chromosomal mapping of A1 and A2 adenosine receptors, VIP receptor, and a new subtype of serotonin receptor

Genomics. 1991 Sep;11(1):225-7. doi: 10.1016/0888-7543(91)90125-x.

Authors

F Libert¹, E Passage, M Parmentier, M J Simons, G Vassart, M G Mattei

Affiliation

¹ Institut de recherche Interdisciplinaire, Faculté de Médecine, Université libre de Bruxelles, Belgium.

PMID: 1662665
DOI: 10.1016/0888-7543(91)90125-x

Abstract

cDNA clones encoding four new receptors of the G-protein-coupled receptor family were obtained by selective amplification and cloning from thyroid cDNA and termed RDC1, RDC4, RDC7, and RDC8. RDC7 and RDC8 have recently been identified as A1 and A2 adenosine receptors, respectively. These cDNAs were utilized for chromosomal in situ hybridization to establish the genomic location of the corresponding genes in man. The results indicate that human RDC1, RDC4, RDC7, and RDC8 are in regions 2q37, 1p34.3-1p36.3, 22q11.2-22q13.1, and 11q11-11q13, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Banding
Chromosome Mapping*
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 22
Cloning, Molecular
Humans
Receptors, Gastrointestinal Hormone / genetics*
Receptors, Gastrointestinal Hormone / metabolism
Receptors, Purinergic / genetics*
Receptors, Serotonin / genetics*
Receptors, Vasoactive Intestinal Peptide
Vasoactive Intestinal Peptide / metabolism*

Substances

Receptors, Gastrointestinal Hormone
Receptors, Purinergic
Receptors, Serotonin
Receptors, Vasoactive Intestinal Peptide
Vasoactive Intestinal Peptide