The Sp1 transcription factor gene (SP1) and the 1,...[Genomics. 1991]

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1: Genomics. 1991 Sep;11(1):168-73. Links

The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7.

Szpirer J, Szpirer C, Riviere M, Levan G, Marynen P, Cassiman JJ, Wiese R, DeLuca HF.

Département de Biologie Moléculaire, Université Libre de Bruxelles, Belgium.

By means of somatic cell hybrids segregating either human or rat chromosomes, the genes encoding the transcription factor Sp1 (SP1) and the 1,25-dihydroxyvitamin D3 receptor (VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This result implies that the locus for the clinical disorder vitamin D dependency rickets type II maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-gamma (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on these chromosomes.

PMID: 1662663 [PubMed - indexed for MEDLINE]

Localization of the transcription factor SP1 gene to human chromosome 12q12-->q13.2.
Cytogenet Cell Genet. 1993; 64(3-4):210-2.

[Cytogenet Cell Genet. 1993]
An ochre mutation in the vitamin D receptor gene causes hereditary 1,25-dihydroxyvitamin D3-resistant rickets in three families.
Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9783-7.

[Proc Natl Acad Sci U S A. 1989]
Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1 alpha,25-dihydroxyvitamin D3 receptor.
Mol Cell Endocrinol. 1990 Mar 26; 70(1):1-11.

[Mol Cell Endocrinol. 1990]
ReviewThe vitamin D hormone and its nuclear receptor: molecular actions and disease states.
J Endocrinol. 1997 Sep; 154 Suppl:S57-73.

[J Endocrinol. 1997]
ReviewNew understanding of the molecular mechanism of receptor-mediated genomic actions of the vitamin D hormone.
Bone. 1995 Aug; 17(2 Suppl):33S-38S.

[Bone. 1995]
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Cited by 2 PubMed Central articles

Nuclear receptors modulate the interaction of Sp1 and GC-rich DNA via ternary complex formation.
Husmann M, Dragneva Y, Romahn E, Jehnichen P. Biochem J. 2000 Dec 15; 352 Pt 3:763-72.

[Biochem J. 2000]
An alternatively spliced form of the transcription factor Sp1 containing only a single glutamine-rich transactivation domain.
Persengiev SP, Saffer JD, Kilpatrick DL. Proc Natl Acad Sci U S A. 1995 Sep 26; 92(20):9107-11.

[Proc Natl Acad Sci U S A. 1995]

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Calcitriol (Rocaltrol® )
Calcitriol is a form of vitamin D that is used to treat and prevent low levels of calcium in the blood of patients whose kidneys or parathyroid glands (glands in the neck that release natural substances to control the am...
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The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VD...The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7.

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The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7.

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Cited by 2 PubMed Central articles

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