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Org Lett. 2006 Apr 27;8(9):1897-900.

Hybridization of pyrrolidinyl peptide nucleic acids and DNA: selectivity, base-pairing specificity, and direction of binding.

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  • 1Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.


[structure: see text] A mixed-base, beta-amino acid containing, pyrrolidinyl peptide nucleic acid (PNA) binds strongly and selectively to complementary DNA in an exclusively antiparallel fashion. The PNA-DNA binding specificity strictly follows the Watson-Crick base-pairing rules.

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