Infect Control Hosp Epidemiol. 2006 Apr;27(4):413-5. Epub 2006 Mar 17.

Identification of optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection: potential role of a Combination Antibiogram.

Mizuta M, Linkin DR, Nachamkin I, Fishman NO, Weiner MG, Sheridan A, Lautenbach E.

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Division of Infectious Diseases, Department of Medicine, University of Pennsylvania School of Medicine, 423 Guardian Drive, Philadelphia, PA 19104, USA.

Abstract

To better determine the optimal combinations for empirical dual antimicrobial therapy of Pseudomonas aeruginosa infection, we evaluated the utility of a novel combination antibiogram. Although the combination antibiogram allowed modest fine-tuning of choices for dual antibiotic therapy, selections based on the 2 antibiograms did not differ substantively. Drug combinations with the broadest coverage were consistently composed of an aminoglycoside and a beta-lactam.

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Infect Control Hosp Epidemiol. 2008 Jul;29(7):678-9.

PMID:: 16622822; [PubMed - indexed for MEDLINE]

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Research Support, N.I.H., Extramural

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Anti-Bacterial Agents

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