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    Mol Genet Metab. 2006 Jul;88(3):290-4. Epub 2006 Apr 18.

    The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels.

    Parle-McDermott A, Mills JL, Molloy AM, Carroll N, Kirke PN, Cox C, Conley MR, Pangilinan FJ, Brody LC, Scott JM.

    School of Biochemistry and Immunology, Trinity College Dublin, Ireland.

    Individuals homozygous for the thermolabile variant (677TT) of methylenetetrahydrofolate reductase exhibit reduced folate status as evidenced by a drop in the biomarker red cell folate (RCF) compared to those who carry at least one 677C allele. We now report that a different polymorphism in the same enzyme, namely 1298A>C, is associated with increased RCF levels. Thus, these two common polymorphisms change a metabolic phenotype in opposite directions suggesting that their cancer protective associations are by different mechanisms.

    PMID: 16621645 [PubMed - indexed for MEDLINE]

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      Folic acid is used to treat or prevent folic acid deficiency. It is a B-complex vitamin needed by the body to manufacture red blood cells. A deficiency of this vitamin causes certain types of anemia (low red blood cell c...

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