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Bioinformatics. 2006 Jun 15;22(12):1532-3. Epub 2006 Apr 13.

FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster.

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  • 1MRC Laboratory of Molecular Biology Cambridge CB2 2QH, UK. boris@mrc-lmb.cam.ac.uk

Abstract

SUMMARY:

We present a manually annotated catalogue of site-specific transcription factors (TFs) in the fruit fly Drosophila melanogaster. These were identified from a list of candidate proteins with transcription-related Gene Ontology (Go) annotation as well as structural DNA-binding domain assignments. For all 1052 candidate proteins, a defined set of rules was applied to classify information from the literature and computational data sources with respect to both DNA-binding and transcriptional regulatory properties. We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins.

PMID:
16613907
[PubMed - indexed for MEDLINE]
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