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Inflamm Allergy Drug Targets. 2006 Jan;5(1):61-77.

Current options in the treatment of mast cell mediator-related symptoms in mastocytosis.

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  • 1Unidad de Mastocitosis, Laboratorio K.Frank Austen, Hospital Ramón y Cajal, Red Española de Mastocitosis, Madrid, Spain. lescribano.hrc@salud.madrid.org

Abstract

Patients with mastocytosis have symptoms related to the tissue response to the release of mediators from mast cells (MC), local mast cell burden or associated non-mast cell hematological disorders. MC contain an array of biologically active mediators in their granules, which are preformed and stored. MC are also able to produce newly generated membrane-derived lipid mediators and are a source of multifunctional cytokines. Mediator-related symptoms can include pruritus, flushing, syncope, gastric distress, nausea and vomiting, diarrhea, bone pain and neuropsychiatric disturbances; these symptoms are variably controlled by adequate medications. Management of patients within all categories of mastocytosis includes: a) a careful counseling of patients (parents in pediatric cases) and care providers, b) avoidance of factors triggering acute mediator release, c) treatment of acute and chronic MC-mediator symptoms and, if indicated, d) an attempt for cytoreduction and treatment of organ infiltration by mast cells.

PMID:
16613565
[PubMed - indexed for MEDLINE]
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