Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Twin Res Hum Genet. 2006 Feb;9(1):1-8.

Genotype x Environment interaction in psychopathology: fact or artifact?

Author information

  • Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA. eaves@mail2.vcu.edu

Abstract

Recent studies have claimed to detect interaction between candidate genes and specific environmental factors (Genotype x Environment interaction, G x E) in susceptibility to psychiatric disorder. The objective of the present study was to examine possible artifacts that could explain widely publicized findings. The additive effects of candidate genes and measured environment on liability to disorder were simulated under a model that allowed for mixture of distributions in liability conditional on genotype and environment. Simulated liabilities were dichotomized at a threshold value to reflect diagnosis of disorder. Multiple blocks of simulated data were analyzed by standard statistical methods to test for the main effects and interactions of genes and environment on outcome. The main outcome of this study was simulated liabilities and diagnoses of major depression and antisocial behavior. Analysis of the dichotomized data by logistic regression frequently detected significant G x E interaction even though none was present for liability. There is therefore reason to question the biological significance of published findings.

PMID:
16611461
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk