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    Rejuvenation Res. 2006 Spring;9(1):89-93.

    Membership in genetic groups predicts Alzheimer disease.

    Corder EH, Huang R, Cathcart HM, Lanham IS, Parker GR, Cheng D, Smith S, Poduslo SE.

    Source

    Center for Demographic Studies, Duke University, Durham, North Carolina, USA.

    Abstract

    The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3:GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TT; and (c) APOE34 and LDLr13:TC. Consonance with one of the groups and high aggregate membership carried >800-fold elevated risk for AD. The absence of these combinations defined low risk. APOE3/- with heterozygous promoter and receptor genotypes predicted long life without dementia.

    PMID:
    16608402
    [PubMed - indexed for MEDLINE]

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