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Nano Lett. 2006 Apr;6(4):669-76.

Peptide-labeled near-infrared quantum dots for imaging tumor vasculature in living subjects.

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  • 1Molecular Imaging Program (MIPS), Department of Radiology, Stanford University School of Medicine, Stanford, California 94305, USA.

Abstract

We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.

PMID:
16608262
[PubMed - indexed for MEDLINE]
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