Nucl Recept Signal. 2003;1:e006. Epub 2003 Jun 27.

PPAR-gamma: a thrifty transcription factor.

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Institut de Genetique et Biologie Moleculaire et Cellulaire (IGBMC) and and Institut Clinique de la Souris (ICS), 67404 Illkirch, France. auwerx@igbmc.u-strasbg.fr

Abstract

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-gamma as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.

PMID:: 16604178; [PubMed]
PMCID:: PMC1402226

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