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Nat Biotechnol. 2006 Apr;24(4):423-5.

What are DNA sequence motifs?

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  • 1Microbial Systems Division, Biosciences Directorate, Lawrence Livermore National Laboratory, PO Box 808, L-448, Livermore, California 94551, USA.


Sequence motifs are becoming increasingly important in the analysis of gene regulation. How do we define sequence motifs, and why should we use sequence logos instead of consensus sequences to represent them? Do they have any relation with binding affinity? How do we search for new instances of a motif in this sea of DNA?

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