- Erratum in:
- Diabetes Res Clin Pract. 2007 Apr;76(1):159-60.
A single transplantation of the islets can produce glycemic stability and reduction of basal insulin requirement.
Sassa M,
Fukuda K,
Fujimoto S,
Toyoda K,
Fujita Y,
Matsumoto S,
Okitsu T,
Iwanaga Y,
Noguchi H,
Nagata H,
Yonekawa Y,
Ohara T,
Okamoto M,
Tanaka K,
Seino Y,
Inagaki N,
Yamada Y.
Department of Diabetes and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan.
We investigated glycemic stability and insulin requirement 1 month after a single transplantation of the islets from non-heart-beating donors or a living donor. Overall blood glucose levels decreased immediately after transplantation. The M-value and mean amplitude of glycemic excursions (MAGE) decreased significantly from 53.0 (range, 8.9-91.0) to 4.2 (0.6-8.8, P<0.05) and from 8.5 mM (4.8-11.7) to 3.3 mM (2.0-4.5, P<0.05), respectively. The values after transplantation were lower than the first quartile of 102 type 2 diabetic control patients. The estimated HbA1c level decreased significantly from 7.9% (5.7-10.9) to 5.4% (4.7-5.9, P<0.05). The supplement of basal insulin decreased 43% from 0.31 units/kg/day (0.16-0.37) to 0.18 units/kg/day (0-0.22, P<0.05), while that of stimulated insulin did not decrease significantly, from 0.28 units/kg/day (0.13-0.51) to 0.21 units/kg/day (0-0.41). Thus, only one islet transplantation can be sufficient to attain metabolic stability, probably by effective supply of basal insulin secretion, sufficient to avoid life-threatening severe hypoglycemia and prevent or delay the progress of secondary complications of diabetes by decreasing the HbA1c level.
PMID: 16600414 [PubMed - indexed for MEDLINE]