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Appl Environ Microbiol. 2006 Apr;72(4):3050-3.

Safety assessment of the oral cavity probiotic Streptococcus salivarius K12.

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  • 1BLIS Technologies, Centre for Innovation, University of Otago, P.O. Box 56, Dunedin, New Zealand.


Streptococcus salivarius is a prominent member of the oral microbiota and has excellent potential for use as a probiotic targeting the oral cavity. In this report we document safety data relating to S. salivarius K12, including assessment of its antibiogram, metabolic profiles, and virulence determinants, and we examine the microbial composition of saliva following the dosing of subjects with K12.

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