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1: Arch Virol. 1991;120(3-4):297-304.Links

Adaptation and serial passage of porcine group C rotavirus in ST-cells, an established diploid swine testicular cell line.

Welter MW, Welter CJ, Chambers DM, Svensson L.

Ambico, Inc., Dallas Center, Iowa.

A porcine group C rotavirus (strain Cowden-AmC-1) was adapted and serially passaged in an established diploid swine testicular cell line (ST cells). Growth of group C rotavirus in ST cells, which in maintenance medium required trypsin, but not pancreatin resulted in cytopathic effect characterized by cellular stranding and subsequent cell lysis. Active replication and assembly were confirmed by RNA profile analysis, immune electron microscopy and immunofluorescence. Adaptation of non-group A rotavirus to a continuous cell line has not previously been reported and should facilitate progress in diagnostic procedures and vaccine development.

PMID: 1659801 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Rotavirus Vaccine (Rotarix® , RotaTeq® )

    Rotavirus is a virus that causes severe diarrhea, mostly in babies and young children. It is often accompanied by vomiting and fever. Rotavirus is not the only cause of severe diarrhea, but it is one of the most serious....

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