Curr Opin Immunol. 2006 Jun;18(3):331-7. Epub 2006 Apr 4.

Private specificities of heterologous immunity.

Source

Department of Pathology and Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA. raymond.welsh@umassmed.edu

Abstract

Antiviral T-cell responses between individuals that have similar major histocompatibility complex molecules share similarities in epitope hierarchies and T-cell receptor variable gene usage (public specificities), yet the T-cell receptor amino acid sequences differ between individuals (private specificities). The significance of the private specificities of these repertoires is brought about under conditions of heterologous immunity and might have important consequences in anti-viral immunity and immunopathology.

PMID:: 16597500; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Receptors, Antigen, T-Cell

Grant Support

AR35506/AR/NIAMS NIH HHS/United States

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