Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver

Biochim Biophys Acta. 1991 Oct 15;1086(1):139-40. doi: 10.1016/0005-2760(91)90165-e.

Abstract

Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250 micrograms/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Male
  • Membrane Proteins*
  • Mitochondria, Liver / enzymology*
  • Phosphotransferases / drug effects*
  • Rats
  • Rats, Inbred Strains
  • Stimulation, Chemical
  • Thyroxine / pharmacology*
  • Transferases (Other Substituted Phosphate Groups)*

Substances

  • Membrane Proteins
  • Phosphotransferases
  • Transferases (Other Substituted Phosphate Groups)
  • cardiolipin synthetase
  • Thyroxine