Abstract
Cardiolipin is a major mitochondrial membrane lipid and plays a vital role in mitochondrial function. The effect of thyroxine on the activity of liver mitochondrial cardiolipin synthase was examined in this study. Treatment with thyroxine (250 micrograms/100 g) for 5 days increased cardiolipin synthase activity by 52%. Mitochondrial levels of cardiolipin appear to be regulated in part by the effect of thyroid hormone on the activity of cardiolipin synthase.
Publication types
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Male
-
Membrane Proteins*
-
Mitochondria, Liver / enzymology*
-
Phosphotransferases / drug effects*
-
Rats
-
Rats, Inbred Strains
-
Stimulation, Chemical
-
Thyroxine / pharmacology*
-
Transferases (Other Substituted Phosphate Groups)*
Substances
-
Membrane Proteins
-
Phosphotransferases
-
Transferases (Other Substituted Phosphate Groups)
-
cardiolipin synthetase
-
Thyroxine