Trends Pharmacol Sci. 1991 Aug;12(8):297-303.

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences.

Source

Department of Pharmacology and Therapeutics, University of Leicester, UK.

Abstract

The ability of lithium to exert profound and selective psychopharmacological effects to ameliorate manic-depressive psychosis has been the focus of considerable research effort. There is increasing evidence that lithium exerts its therapeutic action by interfering with polyphosphoinositide metabolism in brain and prevention of inositol recycling by an uncompetitive inhibition of inositol monophosphatase. Stefan Nahorski, Ian Ragan and John Challiss discuss this unusual stimulus-dependent form of enzyme inhibition, emphasizing that the selectivity exhibited by lithium depends upon the degree of inositol lipid hydrolysis and polyphosphoinositide dephosphorylation.

PMID:: 1658998; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

Wellcome Trust/United Kingdom

LinkOut - more resources

Molecular Biology Databases

LITHIUM, ELEMENTAL - HSDB

Supplemental Content

Save items

Related citations in PubMed

Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation. [Biochem J. 1993]
Beryllium competitively inhibits brain myo-inositol monophosphatase, but unlike lithium does not enhance agonist-induced inositol phosphate accumulation.
Faraci WS, Zorn SH, Bakker AV, Jackson E, Pratt K. Biochem J. 1993 Apr 15; 291 ( Pt 2):369-74.
Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy. [J Mol Biol. 2002]
Crystal structure of an enzyme displaying both inositol-polyphosphate-1-phosphatase and 3'-phosphoadenosine-5'-phosphate phosphatase activities: a novel target of lithium therapy.
Patel S, Yenush L, Rodríguez PL, Serrano R, Blundell TL. J Mol Biol. 2002 Jan 25; 315(4):677-85.
Review Inhibitors of inositol monophosphatase. [J Enzyme Inhib. 1999]
Review Inhibitors of inositol monophosphatase.
Fauroux CM, Freeman S. J Enzyme Inhib. 1999; 14(2):97-108.
Regulation of inositol monophosphatase in Saccharomyces cerevisiae. [Mol Microbiol. 1997]
Regulation of inositol monophosphatase in Saccharomyces cerevisiae.
Murray M, Greenberg ML. Mol Microbiol. 1997 Aug; 25(3):541-6.
Review Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness. [Clin Chem. 1994]
Review Lithium and the brain: a psychopharmacological strategy to a molecular basis for manic depressive illness.
Lenox RH, Watson DG. Clin Chem. 1994 Feb; 40(2):309-14.

See reviews... See all...

Cited by 24 PubMed Central articles

Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. [Biochim Biophys Acta. 2011]
Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder.
Shimshoni JA, Basselin M, Li LO, Coleman RA, Rapoport SI, Modi HR. Biochim Biophys Acta. 2011 Mar; 1811(3):163-9. Epub 2010 Dec 22.
Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli. [J Biol Chem. 2009]
Structural and biochemical characterization of the type II fructose-1,6-bisphosphatase GlpX from Escherichia coli.
Brown G, Singer A, Lunin VV, Proudfoot M, Skarina T, Flick R, Kochinyan S, Sanishvili R, Joachimiak A, Edwards AM, et al. J Biol Chem. 2009 Feb 6; 284(6):3784-92. Epub 2008 Dec 10.
The effect of lithium on the adrenoceptor-mediated second messenger system in the rat brain. [J Psychiatry Neurosci. 2006]
The effect of lithium on the adrenoceptor-mediated second messenger system in the rat brain.
Devaki R, Shankar Rao S, Nadgir SM. J Psychiatry Neurosci. 2006 Jul; 31(4):246-52.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition a...
Lithium and the phosphoinositide cycle: an example of uncompetitive inhibition and its pharmacological consequences.
Trends Pharmacol Sci. 1991 Aug ;12(8):297-303.

PubMed
BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN.
BACTERIAL PROTOPLASTS INDUCED BY PENICILLIN.
Proc Natl Acad Sci U S A. 1956 Sep ;42(9):574-7.

PubMed
Prevention of deep vein thrombosis by low-molecular-weight heparin and dihydroer...
Prevention of deep vein thrombosis by low-molecular-weight heparin and dihydroergotamine in patients undergoing total hip replacement.
Thromb Res. 1991 Jul 1 ;63(1):133-43.

PubMed
THE EFFECT OF DIABETES AND FASTING ON LIVER GLUCOSE-6-PHOSPHATASE.
THE EFFECT OF DIABETES AND FASTING ON LIVER GLUCOSE-6-PHOSPHATASE.
Proc Natl Acad Sci U S A. 1954 Aug ;40(8):673-8.

PubMed
Neuroleptics in painful thiamine deficiency neuropathy.
Neuroleptics in painful thiamine deficiency neuropathy.
South Med J. 1991 Nov ;84(11):1362-3.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: