Display Settings:

Format

Send to:

Choose Destination
Pflugers Arch. 2007 Feb;453(5):581-9. Epub 2006 Apr 4.

The ABCA subfamily--gene and protein structures, functions and associated hereditary diseases.

Author information

  • 1Physiology Weihenstephan, Technical University Munich, Freising, Germany. Christiane.Albrecht@wzw.tum.de

Abstract

To date, 12 members of the human ABCA subfamily are identified. They share a high degree of sequence conservation and have been mostly related with lipid trafficking in a wide range of body locations. Mutations in some of these genes have been described to cause severe hereditary diseases related with lipid transport, such as fatal surfactant deficiency or harlequin ichthyosis. In addition, most of them are hypothesized to participate in the subcellular sequestration of drugs, thereby being responsible for the resistance of several carcinoma cell lines against drug treatment. The objective of this review is to summarize the literature for this subfamily of ABC transporter proteins, excluding ABCA1 and ABCA4, which will be discussed in other chapters of this issue.

PMID:
16586097
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer
    Loading ...
    Write to the Help Desk