Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Am J Psychiatry. 2006 Apr;163(4):735-8.

Use of FMRI to predict recovery from unipolar depression with cognitive behavior therapy.

Author information

  • 1Western Psychiatric Institute and Clinic, 3811 O'Hara St., Pittsburgh, PA 15213-2593, USA. gsiegle@pitt.edu

Abstract

OBJECTIVE:

In controlled treatment trials, 40%-60% of unmedicated depressed individuals respond to cognitive behavior therapy (CBT). The authors examined whether pretreatment neural reactivity to emotional stimuli accounted for this variation.

METHOD:

Unmedicated depressed individuals (N=14) and never depressed comparison subjects (N=21) underwent fMRI during performance of a task sensitive to sustained emotional information processing. Afterward, depressed participants completed 16 sessions of CBT.

RESULTS:

Participants whose sustained reactivity to emotional stimuli was low in the subgenual cingulate cortex (Brodmann's area 25) and high in the amygdala displayed the strongest improvement with CBT.

CONCLUSIONS:

The presence of emotion regulation disruptions, which are targeted in CBT, may be the key to recovery with this intervention.

PMID:
16585452
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Silverchair Information Systems
    Loading ...
    Write to the Help Desk