J Affect Disord. 1991 Aug;22(4):185-90.

Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS.

Kato T, Shioiri T, Takahashi S, Inubushi T.

Source

Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan.

Abstract

In vivo phosphorus-31 magnetic resonance spectroscopy (31P-MRS) was used to measure phosphorus metabolism in the brains of manic patients treated with lithium carbonate. The phosphomonoester (PME) peak was elevated in the manic state in patients with DSM-IIIR bipolar disorder compared to the euthymic state and to drug-free normal controls. Elevation of the PME peak may be caused by lithium-induced accumulation of inositol 1-phosphate in the brain.

PMID:: 1658103; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Medical

Bipolar Disorder - MedlinePlus Health Information

Molecular Biology Databases

LITHIUM CARBONATE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. [J Affect Disord. 1993]
Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy.
Kato T, Takahashi S, Shioiri T, Inubushi T. J Affect Disord. 1993 Jan; 27(1):53-9.
Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients. [Hum Psychopharmacol. 2002]
Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients.
Silverstone PH, Wu RH, O'Donnell T, Ulrich M, Asghar SJ, Hanstock CC. Hum Psychopharmacol. 2002 Oct; 17(7):321-7.
Relationship of lithium concentrations in the brain measured by lithium-7 magnetic resonance spectroscopy to treatment response in mania. [J Clin Psychopharmacol. 1994]
Relationship of lithium concentrations in the brain measured by lithium-7 magnetic resonance spectroscopy to treatment response in mania.
Kato T, Inubushi T, Takahashi S. J Clin Psychopharmacol. 1994 Oct; 14(5):330-5.
Review Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients. [World J Biol Psychiatry. 2004]
Review Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients.
Silverstone PH, Asghar SJ, O'Donnell T, Ulrich M, Hanstock CC. World J Biol Psychiatry. 2004 Jan; 5(1):38-44.
Review Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings. [Bipolar Disord. 2005]
Review Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings.
Silverstone PH, McGrath BM, Kim H. Bipolar Disord. 2005 Feb; 7(1):1-10.

See reviews... See all...

Cited by 1 PubMed Central article

Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. [J Psychiatry Neurosci. 1996]
Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder.
Kato T, Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi T. J Psychiatry Neurosci. 1996 Jul; 21(4):248-54.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Measurement of brain phosphoinositide metabolism in bipolar patients using in vi...
Measurement of brain phosphoinositide metabolism in bipolar patients using in vivo 31P-MRS.
J Affect Disord. 1991 Aug ;22(4):185-90.

PubMed
Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 ...
Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals.
Biochem Biophys Res Commun. 2006 May 19 ;343(4):1272-8. Epub 2006 Mar 27 .

PubMed
Positively charged peptides can interact with each other, as revealed by solid p...
Positively charged peptides can interact with each other, as revealed by solid phase binding assays.
Anal Biochem. 2006 May 15 ;352(2):157-68. Epub 2006 Mar 20 .

PubMed
Systematic analysis of the transcriptional switch inducing migration of border c...
Systematic analysis of the transcriptional switch inducing migration of border cells.
Dev Cell. 2006 Apr ;10(4):497-508.

PubMed
Analysis of cell migration using whole-genome expression profiling of migratory ...
Analysis of cell migration using whole-genome expression profiling of migratory cells in the Drosophila ovary.
Dev Cell. 2006 Apr ;10(4):483-95.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: