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Dev Cell. 2006 Apr;10(4):412-3.

Turning off Smads: identification of a Smad phosphatase.

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  • 1Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, United Kingdom.


Although the activation of Smad signaling pathways downstream of TGF-beta superfamily ligands by receptor-mediated Smad phosphorylation is well understood, nothing is known about Smad phosphatases that turn off Smad activity. Recently in Genes & Development, describe pyruvate dehydrogenase phosphatase as a Smad1 phosphatase that functions in Drosophila in the Decapentaplegic pathway and in mammalian cells in the BMP pathway.

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