Science. 2006 Mar 31;311(5769):1880-5.

Stem cells and their niches.

Source

Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Princeton, NJ 08544, USA. kamoore@princeton.edu

Abstract

A constellation of intrinsic and extrinsic cellular mechanisms regulates the balance of self-renewal and differentiation in all stem cells. Stem cells, their progeny, and elements of their microenvironment make up an anatomical structure that coordinates normal homeostatic production of functional mature cells. Here we discuss the stem cell niche concept, highlight recent progress, and identify important unanswered questions. We focus on three mammalian stem cell systems where large numbers of mature cells must be continuously produced throughout adult life: intestinal epithelium, epidermal structures, and bone marrow.

PMID:: 16574858; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Review Stem cell niches in mammals. [Exp Cell Res. 2007]
Review Stem cell niches in mammals.
Mitsiadis TA, Barrandon O, Rochat A, Barrandon Y, De Bari C. Exp Cell Res. 2007 Oct 1; 313(16):3377-85. Epub 2007 Aug 2.
Review Distinct epidermal stem cell compartments are maintained by independent niche microenvironments. [Stem Cell Rev. 2006]
Review Distinct epidermal stem cell compartments are maintained by independent niche microenvironments.
Braun KM, Prowse DM. Stem Cell Rev. 2006; 2(3):221-31.
Hematopoietic stem and progenitor cells and the inflammatory response. [Ann N Y Acad Sci. 2009]
Hematopoietic stem and progenitor cells and the inflammatory response.
Jaiswal S, Weissman IL. Ann N Y Acad Sci. 2009 Sep; 1174:118-21.
Review [Progress in epidermal stem cells]. [Yi Chuan. 2010]
Review [Progress in epidermal stem cells].
Wang LJ, Wang YL, Yang X. Yi Chuan. 2010 Mar; 32(3):198-204.
Review Stem cell niche: structure and function. [Annu Rev Cell Dev Biol. 2005]
Review Stem cell niche: structure and function.
Li L, Xie T. Annu Rev Cell Dev Biol. 2005; 21:605-31.

See reviews... See all...

Cited by over 100 PubMed Central articles

Vascular calcifying progenitor cells possess bidirectional differentiation potentials. [PLoS Biol. 2013]
Vascular calcifying progenitor cells possess bidirectional differentiation potentials.
Cho HJ, Cho HJ, Lee HJ, Song MK, Seo JY, Bae YH, Kim JY, Lee HY, Lee W, Koo BK, et al. PLoS Biol. 2013 Apr; 11(4):e1001534. Epub 2013 Apr 9.
Neural progenitors organize in small-world networks to promote cell proliferation. [Proc Natl Acad Sci U S A. 2013]
Neural progenitors organize in small-world networks to promote cell proliferation.
Malmersjö S, Rebellato P, Smedler E, Planert H, Kanatani S, Liste I, Nanou E, Sunner H, Abdelhady S, Zhang S, et al. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1524-32. Epub 2013 Apr 1.
Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways. [PLoS One. 2013]
Culturing on Wharton's jelly extract delays mesenchymal stem cell senescence through p53 and p16INK4a/pRb pathways.
Hao H, Chen G, Liu J, Ti D, Zhao Y, Xu S, Fu X, Han W. PLoS One. 2013; 8(3):e58314. Epub 2013 Mar 13.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Stem cells and their niches.
Stem cells and their niches.
Science. 2006 Mar 31 ;311(5769):1880-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Stem cells and their niches.

Source

Abstract

Publication Types, MeSH Terms

Publication Types

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by over 100 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information