Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2006 Jun;18(3):267-74. Epub 2006 Mar 30.

Chromatin remodelling and transcription: be-WICHed by nuclear myosin 1.

Author information

  • 1Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, P.O. Box 285, Stockholm SE-171 77, Sweden. piergiorgio.percipalle@ki.se


Transcription in eukaryotic cells requires dynamic changes of chromatin structure to facilitate or prevent RNA polymerase access to active genes. These structural modifications rely on the concerted action of ATP-dependent chromatin-remodelling complexes and histone-modifying enzymes, which generate a chromatin configuration that is either compatible with transcription (euchromatin) or incompatible (heterochromatin). Insights into how these structural changes might be coordinated for RNA polymerase I (pol I) genes come from the discoveries of the nucleolar-remodelling complex (NoRC) and B-WICH--a high molecular weight fraction of the WSTF/SNF2h chromatin-remodelling complex. NoRC produces a repressive chromatin state; B-WICH, together with nuclear myosin 1, activates pol I transcription directly on chromatin templates and might also function in the maintenance of ribosomal chromatin structure.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk