Brain Res. 1991 Jul 12;553(2):327-30.

MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy.

Davar G, Hama A, Deykin A, Vos B, Maciewicz R.

Source

Pain Physiology Laboratory, Massachusetts General Hospital, Charlestown 02129.

Abstract

Loose ligation of the sciatic nerve in the rat can produce behavioral signs of hyperalgesia in the hindpaw. This study examined the effect of an NMDA (N-methyl-D-aspartate) receptor antagonist (MK-801) on the development of hyperalgesia in this model. Rats received i.p. injections of saline or MK-801 (1.0 mg/kg) prior to and then for 7 days after a unilateral sciatic nerve ligation. Testing of each hindpaw for latency to withdrawal from a standardized thermal stimulus was performed prior to ligation and then at 10, 12, 17, 27, and 37 days postoperatively. Hyperalgesia of the operated hindpaw developed in saline-treated animals as measured by a decrease in withdrawal latency. Hyperalgesia did not develop in animals treated with MK-801. MK-801 may therefore prevent the development of hyperalgesia following experimental nerve injury, possibly through an NMDA receptor-mediated effect.

PMID:: 1657283; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Dizocilpine Maleate

Grant Support

IF32NS085 34-02/NS/NINDS NIH HHS/United States

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Elsevier Science

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New England Research Institutes Inc.

Medical

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Chemical compound information

Dizocilpine Maleate

MW: 221.29 g/mol

MF: C₁₆H₁₅N

See 1 citation for this compound....

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