Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Neurosci. 2006 Mar 29;26(13):3584-8.

Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate-putamen.

Author information

  • 1Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Abstract

Cue-induced reinstatement of extinguished drug seeking is a preclinical model of relapse. However, relapse typically occurs after abstinence rather than explicit extinction training. We show that inactivation of the dorsolateral caudate-putamen, but not other structures previously implicated in reinstatement, attenuates cocaine seeking after abstinence. This suggests that there is limited overlap in the substrates of cocaine seeking after abstinence versus extinction, and that habit learning exerts greater control over drug seeking than regions implicated in stimulus-reward associations.

PMID:
16571766
[PubMed - indexed for MEDLINE]
PMCID:
PMC1643847
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk