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Arzneimittelforschung. 2006 Feb;56(2A):121-35.

Stampidine as a novel nucleoside reverse transcriptase inhibit with potent anti-HIV activity.

Author information

  • Parker Hughes Institute, Roseville, Minnesota, USA. fatih_uckun@ih.org

Abstract

Stavudine (STV, d4T, 2',3'-didehydro-3'-deoxythymidine, CAS 3056-17-5) is a standard anti-HIV drug. Stampidine (STAMP, DDE-113, HI-113, N-[p-(4-bromophenyl)-2',3'-didehydro-3'-deoxy-5'-thymidylyl]-L-alanine methyl ester, CAS 217178-62-6) is a novel aryl phosphate derivative of stavudine with more potent anti-HIV activity and more favorable pharmacodynamic features. The remarkable potency of stampidine against clinical HIV-1 isolates with NRTI- or NNRTI-resistance (NRTI, nucleoside reverse transcriptase inhibitor; NNRTI, non-nucleoside reverse transcriptase inhibitor) warrants the further development of this new anti-HIV agent.

PMID:
16570821
[PubMed - indexed for MEDLINE]
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