Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Jan;20(2):78-80.

[Expression of perlecan in laryngeal carcinoma cell and its significance].

[Article in Chinese]

Chen G, Ding J, Luo L, Liu Y, Yan K, Chen P, Song P, Fu Y, Wang J, Gong S.

Source

Department of Otolaryngology, Union Hospital, Huazhong University of Science and Technology, Wuhan 430022, China.

Abstract

OBJECTIVE:

To study the expression of perlecan in human laryngeal carcinoma cells and its significance.

METHOD:

The expression of perlecan mRNA in human laryngeal carcinoma cells, Hep-2 cells were investigated by using the techniques of semi-quantify RT-PCR. The expression of perlecan in the Hep-2 cells was investigated by using the techniques of immunohistochemistry.

RESULT:

It showed that the expression level of perlecan and perlecan mRNA significantly increased in Hep-2 cells as compared with the normal cells, Hacat cells (P < 0.01).

CONCLUSION:

These data raise the possibility that perlecan many play key roles in the growth,invasion and metastasis of human laryngeal carcinoma cells through either a paracrine or an autocrine mechanism.

PMID:: 16570819; [PubMed - indexed for MEDLINE]

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