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1: Antimicrob Agents Chemother. 2006 Apr;50(4):1552-4.Click here to read Click here to read Links

In vivo efficacy of aerosolized nanostructured itraconazole formulations for prevention of invasive pulmonary aspergillosis.

Hoeben BJ, Burgess DS, McConville JT, Najvar LK, Talbert RL, Peters JI, Wiederhold NP, Frei BL, Graybill JR, Bocanegra R, Overhoff KA, Sinswat P, Johnston KP, Williams RO 3rd.

University of Texas Health at Austin College of Pharmacy, TX, USA.

Aerosolized evaporative precipitation into aqueous solution and spray freezing into liquid nanostructured formulations of itraconazole as prophylaxis significantly improved survival relative to commercial itraconazole oral solution and the control in a murine model of invasive pulmonary aspergillosis. Aerosolized administration of nanostructured formulations also achieved high lung tissue concentrations while limiting systemic exposure.

PMID: 16569882 [PubMed - indexed for MEDLINE]

PMCID: PMC1426984

Patient Drug Information

  • Itraconazole (Sporanox® )

    Itraconazole capsules are used to treat fungal infections that begin in the lungsand can spread through the body. Itraconazole capsules are also used to treat fungal infections of the fingernails and/or toenails. Itracon...

  • Source: AHFS Consumer Medication Information