Format

Send to:

Choose Destination
See comment in PubMed Commons below
Semin Cell Dev Biol. 2006 Apr;17(2):274-84. Epub 2006 Mar 2.

Regulation of fertilization-initiated [Ca2+]i oscillations in mammalian eggs: a multi-pronged approach.

Author information

  • 1Molecular and Cellular Biology Program, University of Massachusetts, Amherst, 01003, USA.

Abstract

The calcium ([Ca(2+)](i)) oscillations associated with mammalian fertilization and required to induce egg activation occur during M-phase stages of the cell cycle. The molecular mechanisms underlying this regulation remain unproven and may be multi-layered. Type 1 inositol 1,4,5-trisphosphate receptors (IP(3)R-1), which mediate [Ca(2+)](i) release during fertilization, have emerged as key regulatory units because they contain multiple phosphorylation consensus sites and undergo changes in cellular location and mass prior to and following fertilization. Hence, control of IP(3)R-1 function together with regulation of PLCzeta activity, the putative sperm factor, may combine to impart cell cycle and species-specific [Ca(2+)](i) oscillations characteristic of mammalian fertilization.

PMID:
16569507
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk