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J Am Chem Soc. 2006 Apr 5;128(13):4168-9.

Multifunctional polymeric nanoparticles from diverse bioactive agents.

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  • 1Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113, USA.


We present a rational approach for assembling diverse bioactive agents, such as DNA, proteins, and drug molecules, into core-shell multifunctional polymeric nanoparticles (PNPs) that can be internalized in human breast cancer cells. Using ring-opening metathesis polymerization (ROMP), block copolymers containing small-molecule drug segments (>50% w/w) and tosylated hexaethylene glycol segments were prepared and assembled into PNPs that allowed for the surface conjugation of single-stranded DNA sequences and/or tumor-targeting antibodies. The resulting antibody-functionalized particles were readily uptaken by breast cancer cells that overexpressed the corresponding antigens.

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