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J Child Neurol. 2006 Feb;21(2):145-8.

Nonprogressive familial leukoencephalopathy with porencephalic cyst and focal seizures.

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  • 1Pediatric Neurology Unit, Wolfson Medical Center, Holon, Israel.


Two siblings with a similar white-matter disease but different clinical symptoms are described. The first sibling suffers from nonprogressive spastic hemiparesis secondary to a congenital periventricular porencephalic cyst. Her brother has focal epilepsy. On magnetic resonance imaging, both patients show diffuse white-matter involvement predominantly of the posterior periventricular area. We suggest that this is a familial white-matter disorder with minimal symptoms and no progression in early childhood.

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