Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Allergy Asthma Rep. 2006 Mar;6(2):153-9.

Novel foods to treat food allergy and gastrointestinal infection.

Author information

  • Evolving Foods and Children's Health, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, California Pacific Medical Center, Box 7999, San Francisco, 94120, USA. hperr@itsa.ucsf.edu

Abstract

The gastrointestinal tract communicates directly with the external environment. Necessary nutrients must be absorbed and commensal bacteria tolerated, and foreign proteins, antigens, and pathogens must be simultaneously excluded or destroyed. Immaturity or disruption of the mucosal immune defenses increases vulnerability to food allergy, intolerance, and infectious disease. Diseases resulting from ingested foreign proteins and organisms are increasing and cause morbidity and mortality worldwide. There is no specific treatment for food allergy other than avoidance. Vaccination for infectious disease is limited by the cost and logistics of distribution and administration, particularly in developing countries. Novel strategies are being explored to modulate the gut mucosal immune system by altering protein expression in food. Crops are being developed to remove deleterious allergens to prevent immunogenic exposure while preserving nutritional quality. Local food plants that express protein fragments of pathogens might provide an effective means to stimulate gut mucosal immunity while increasing vaccine accessibility.

PMID:
16566866
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk