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    BMC Genomics. 2006 Mar 27;7:63.

    Exploring the reasons for the large density of triplex-forming oligonucleotide target sequences in the human regulatory regions.

    Goñi JR, Vaquerizas JM, Dopazo J, Orozco M.

    Source

    Molecular Modeling and Bioinformatics Unit, Institut de Recerca Biomèdica, Parc Científic de Barcelona, Josep Samitier 1-5, Barcelona 08028, Spain. rgoni@mmb.pcb.ub.es

    Abstract

    BACKGROUND:

    DNA duplex sequences that can be targets for triplex formation are highly over-represented in the human genome, especially in regulatory regions.

    RESULTS:

    Here we studied using bioinformatics tools several properties of triplex target sequences in an attempt to determine those that make these sequences so special in the genome.

    CONCLUSION:

    Our results strongly suggest that the unique physical properties of these sequences make them particularly suitable as "separators" between protein-recognition sites in the promoter region.

    PMID:
    16566817
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC1435886
    Free PMC Article

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