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    Nat Med. 2006 Apr;12(4):395-7. Epub 2006 Mar 26.

    Human sebaceous tumors harbor inactivating mutations in LEF1.

    Takeda H, Lyle S, Lazar AJ, Zouboulis CC, Smyth I, Watt FM.

    Source

    Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.

    Abstract

    We found that one-third of human sebaceous tumors examined had double-nucleotide substitutions in the same LEF1 allele, irrespective of DNA mismatch repair status. The mutations impaired both LEF1 binding to beta-catenin and transcriptional activation, and are the first tumor-associated mutations that inactivate Wnt signaling. Mutant LEF1 not only inhibited expression of beta-catenin target genes but also stimulated expression of sebocyte markers, suggesting that it may determine the differentiated characteristics of sebaceous tumors.

    PMID:
    16565724
    [PubMed - indexed for MEDLINE]

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