Cell. 2006 Mar 24;124(6):1123-5.

Increasingly irritable and close to tears: TRPA1 in inflammatory pain.

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London Pain Consortium, King's College London, London WC2R 2LS, United Kingdom. stephen.mcmahon@kcl.ac.uk

Abstract

TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice.

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TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. [Cell. 2006]
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.Bautista DM, Jordt SE, Nikai T, Tsuruda PR, Read AJ, Poblete J, Yamoah EN, Basbaum AI, Julius D. Cell. 2006 Mar 24; 124(6):1269-82.

PMID:: 16564004; [PubMed - indexed for MEDLINE]

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