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Cell. 2006 Mar 24;124(6):1123-5.

Increasingly irritable and close to tears: TRPA1 in inflammatory pain.

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  • 1London Pain Consortium, King's College London, London WC2R 2LS, United Kingdom.


TRP cation channels transduce mechanical, thermal, and pain-related inflammatory signals. In this issue of Cell, it is reported that TRPA1 has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, including those found in tear gas and garlic. In contrast, mechano- and thermosensation are normal in TRPA1-deficient mice.

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